SYNOPSIS: In a trial comparing naproxyn alone to combinations with cyclobenzaprine or oxycodone/acetaminophen in patients with acute low back pain, there was no difference in outcome after 1 week.
SOURCE: Friedman B, et al. Naproxyn with cyclobenzaprine, oxycodone/acetaminophen, or placebo for treating acute low back pain. A randomized clinical trial. JAMA 2015;314:1572-1580.