Selective Disruption of Thalamo-Cortical Connections in Patients with Disorders of Consciousness — a Possible Biomarker for Cognitive-Motor Dissociation

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SYNOPSIS: In this case-control, functional neuroimaging study, the authors developed a novel method to evaluate correlations between integrity of neural circuits involved in overt and covert motor behavior and apply the method to two patients: one with a dissociation of imaging-based vs bedside evidence of command following and one without.

SOURCE: Fernández-Espejo D, et al. A thalamocortical mechanism for the absence of overt motor behavior in covertly aware patients. JAMA Neurol 2015 Oct 19:1-9. doi: 0.1001/jamaneurol.2015.2614. [Epub ahead of print].

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