Postmortem Evidence of Limbic, Neocortical, and Basal Ganglia Deficits in Parkinson's Disease Dementia

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Abstract

SYNOPSIS: Postmortem brain tissue from 15 individuals with Parkinson's disease dementia was analyzed by high-performance liquid chromatography and immunoassays, revealing widespread deficits in dopamine, serotonin, and noradrenaline innervation.

SOURCE: Buddhala C, et al. Dopaminergic, serotonergic, and noradrenergic deficits in Parkinson disease. Ann Clin Transl Neurol 2015;2:949-959.

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