Serotonin Transporter Increases in Premotor Parkinson’s Disease

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In a small cross-sectional study, increased serotonin transporter was detected using 11C-DASB PET in striatum, hypothalamus, and brainstem in LRRK2 carriers who did not have clinical Parkinson’s disease. This contrasts with later decreases previously described and implies a likely early compensatory mechanism.

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