Electroencephalogram and brainstem auditory evoked potential in 539 patients with central coordination disorder


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Abstract

BACKGROUND:Electroencephalogram (EEG) and brainstem auditory evoked potential (BAEP) are objective non-invasive means of measuring brain electrophysiology.OBJECTIVE:To analyze the value of EEG and BAEP in early diagnosis, treatment and prognostic evaluation of central coordination disorder.DESIGN, TIME AND SETTING:This case analysis study was performed at the Rehabilitation Center of Hunan Children's Hospital from January 2002 to January 2006.PARTICIPANTS:A total of 593 patients with severe central coordination disorder, comprising 455 boys and 138 girls, aged 1–6 months were enrolled for this study.METHODS:EEG was monitored using electroencephalography. BAEP was recorded using a Keypoint electromyogram device. Intelligence was tested by professionals using the Gesell scale.MAIN OUTCOME MEASURES:(1) The rate of abnormal EEG and BAEP, (2) correlation of abnormalities of EEG and BAEP with associated injuries, (3) correlation of abnormalities of EEG and BAEP with high risk factors.RESULTS:The rate of abnormal EEG was 68.6% (407/593 patients), and was increased in patients who also had mental retardation (P < 0.05). The rate of abnormal BAEP was 21.4% (127/593 patients). These 127 patients included 67 patients (52.8%) with peripheral auditory damage and 60 patients (47.2%) with central and mixed auditory damage. The rate of abnormal BAEP was significantly increased in patients who also had mental retardation (P < 0.01). Logistic regression analysis showed that asphyxia (P < 0.05), jaundice, preterm delivery, low birth weight and the umbilical cord around the neck were closely correlated with abnormal EEG in patients with central coordination disorder. Intracranial hemorrhage, jaundice (P < 0.05), low birth weight and intrauterine infection (P < 0.05) were closely correlated with abnormal BAEP in patients with central coordination disorder.CONCLUSION:Central coordination disorder is often associated with abnormal EEG and BAEP. The rate of EEG or BAEP abnormality is positively associated with the size of the brain injury. Asphyxia is a high risk factor for abnormal EEG in central coordination disorder. Jaundice and intrauterine infection are high risk factors for abnormal BAEP in central coordination disorder.

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