Status epilepticus increases mature granule cells in the molecular layer of the dentate gyrus in rats**★

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Abstract

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(1) The association between neurogenesis and epilepsy is an active area of research.

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(2) In the hilus, the properties of ectopic granule cells following status epilepticus have been widely studied, but granule cells in the molecular layer are less well understood.

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(3) We studied the distribution of granule cells in the molecular layer after pilocarpine-induced status epilepticus.

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(4) A history of status epilepticus was associated with an increase in the numbers of mature and ectopic newborn granule cells in the molecular layer.

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(5) The abnormal polarization of ectopic granule cells suggests that their electrophysiological properties and synaptic connections may be different from those of normally distributed granule cells.

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