Three-dimensional structure of axonal mitochondria reflects the age of drosophila

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Abstract

Research Highlights

(1) The present study aimed to understand the changes in axonal mitochondria, the imbalance of mitochondrial fission and fusion in neurodegenerative diseases, alterations in mitochondrial morphology, number, volume and distribution, as well as neuronal apoptosis.

Research Highlights

(2) Fiji and Neurolucida software was applied to reconstruct a three-dimensional map of axonal mitochondria and to observe the morphology and distribution of mitochondria in drosophila at different ages.

Research Highlights

(3) We can infer a mitochondrial fission and fusion imbalance and a possible mechanism of age-related neurodegeneration from studying the morphology, number and size of mitochondria.

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