The glucose-inhibited neurons present in the lateral hypothalamic area are regarded as glucose detectors. This structure is involved in the regulation of food intake through extracellular blood glucose concentrations, and plays a crucial role in obesity onset. In the present study, obesity models established with high fat feeding were treated with electroacupuncture at Zusanli (ST36)/Inner Court (ST44) on the left side and Tianshu (ST25) bilaterally. We found that electroacupuncture could effectively reduce body weight and the fat-weight ratio, and decrease serum leptin, resistin, tumor necrosis factor alpha, and neuropeptide Y levels, while increase serum adiponectin and cholecystokinin-8 levels. This treatment altered the electrical activity of glucose-inhibited neurons in the lateral hypothalamic area, with electroacupuncture at Zusanlil Inner Court exerting an inhibitory effect, while electroacupuncture at bilateral Tianshu exerting an excitatory effect. These data suggest that electroacupuncture at the lower limbs and abdominal cavity is an effective means for regulating the activity of glucose-inhibited neurons in the lateral hypothalamic area and for improving the secretory function of adipose tissue.Research Highlights
(1) Electroacupuncture at the lower limbs and abdominal cavity is an effective means for fat weight loss and improvement of secretion function of adipose tissue.Research Highlights
(2) Glucose-inhibited neurons are present in the lateral hypothalamic area, and can be regulated by electroacupuncture treatment at the lower limbs and abdominal cavity. This regulatory action may be one of the mechanisms underlying acupuncture treatment for simple obesity.Research Highlights
(3) Electroacupuncture at different acupoints exerts various effects on the glucose-inhibited neurons in the lateral hypothalamic area.