Previous studies have shown that sericin extracted from silk cocoon significantly reduces blood glucose levels and protects the nervous system against diabetes mellitus. In this study, a rat type 2 diabetes mellitus model was established by intraperitoneal injection of 25 mg/kg streptozotocin for 3 successive days, following which the rats were treated with sericin for 35 days. After treatment, the blood glucose levels of the diabetic rats decreased significantly, the growth hormone level in serum and its expression in the hippocampus decreased significantly, while the insulin-like growth factor-1 level in serum and insulin-like growth factor-1 and growth hormone receptor expression in the hippocampus increased significantly. The experimental findings indicate that sericin improves disorders of the growth hormone/insulin-like growth factor 1 axis to alleviate hippocampal damage in diabetic rats.Research Highlights
(1) The growth hormone/insulin-like growth factor 1 axis is an important anabolic-conditioning tem that plays a critical role in the growth and development of the central nervous system.Research Highlights
(2) Enzyme-linked immunosorbent assay, western blot and reverse transcription-PCR were used to demonstrate the role of sericin in regulating the expression of hippocampal growth mone/insulin-like growth factor 1 in diabetic rats.Research Highlights
(3) Sericin can alleviate diabetic hippocampal damage through improving disorders in the growth hormone/insulin-like growth factor 1.