(1) This study concluded that decimeter wave therapy promoted the proliferation of Schwann cells and elevated S-100 protein expression in injured sciatic nerves, and contributed to neural regeneration and functional recovery at cellular and molecular levels.Research Highlights
(2) Decimeter wave therapy promoted axonal regeneration and remyelination, delayed myatrophy and facilitated neural regeneration and functional recovery.Research Highlights
(3) Decimeter wave therapy inhibited the inflammatory reaction and anticoagulation, improved the local blood circulation, reduced the formation of scar and effectively prevented nerve adhesion and re-entrapment after repairing.
Drug treatment, electric stimulation and decimeter wave therapy have been shown to promote the repair and regeneration of the peripheral nerves at the injured site. This study prepared a Mackinnon's model of rat sciatic nerve compression. Electric stimulation was given immediately after neurolysis, and decimeter wave radiation was performed at 1 and 12 weeks post-operation. Histological observation revealed that intraoperative electric stimulation and decimeter wave therapy could improve the local blood circulation of repaired sites, alleviate hypoxia of compressed nerves, and lessen adhesion of compressed nerves, thereby decreasing the formation of new entrapments and enhancing compressed nerve regeneration through an improved microenvironment for regeneration. Immunohistochemical staining results revealed that intraoperative electric stimulation and decimeter wave could promote the expression of S-100 protein. Motor nerve conduction velocity and amplitude, the number and diameter of myelinated nerve fibers, and sciatic functional index were significantly increased in the treated rats. These results verified that intraoperative electric stimulation and decimeter wave therapy contributed to the regeneration and the recovery of the functions in the compressed nerves.