Oxidative stress, mitochondrial damage and neurodegenerative diseases****○

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Abstract

Research Highlights

(1) Growing evidence has highlighted that oxidative stress and mitochondrial dysfunction may trigger neurodegenerative diseases.

Research Highlights

(2) The contribution of oxidative stress-caused mitochondrial damage in Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis is summarized and analyzed, in a broad attempt to provide evidence for the potential treatment of neurodegenerative diseases.

Oxidative stress and mitochondrial damage have been implicated in the pathogenesis of several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Oxidative stress is characterized by the overproduction of reactive oxygen species, which can induce mitochondrial DNA mutations, damage the mitochondrial respiratory chain, alter membrane permeability, and influence Ca2+ homeostasis and mitochondrial defense systems. All these changes are implicated in the development of these neurodegenerative diseases, mediating or amplifying neuronal dysfunction and triggering neurodegeneration. This paper summarizes the contribution of oxidative stress and mitochondrial damage to the onset of neurodegenerative eases and discusses strategies to modify mitochondrial dysfunction that may be attractive therapeutic interventions for the treatment of various neurodegenerative diseases.

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