Injuries to peripheral nerves are common and cause life-changing problems for patients alongside high social and health care costs for society. Current clinical treatment of peripheral nerve injuries predominantly relies on sacrificing a section of nerve from elsewhere in the body to provide a graft at the injury site. Much work has been done to develop a bioengineered nerve graft, precluding sacrifice of a functional nerve. Stem cells are prime candidates as accelerators of regeneration in these nerve grafts. This review examines the potential of adipose-derived stem cells to improve nerve repair assisted by bioengineered nerve grafts.Funding:
Smith RJP is supported by the Hargreaves and Ball trust. Faroni A and Reid AJ are supported by the National Institute for Health Research, the Academy of Medical Sciences and the British Society for Surgery of the Hand.Funding:
Faroni A, Smith RJP, Reid AJ. Adipose derived stem cells and peripheral nerve regeneration. Neural Regen Res. 2014;9(14):1341-1346.