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“Mono” or infectious mononucleosis is a disease that is of popular concern among college students. It is also one of the least understood of all diseases, its seriousness being grossly exaggerated. Misconceptions regarding mononucleosis are especially prevalent among college students and their parents. The nurse practitioner is in a unique position to dispel longstanding myths through health teaching, an important aspect of the assessment and management of this illness.

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