ATRIAL FIBRILLATION: FIRE or ICE? Cryoablation not inferior, not superior

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Abstract

The primary analysis of FIRE AND ICE demonstrated that cryoablation was noninferior to radiofrequency ablation for the primary efficacy end point of first documented clinical failure. Secondary analysis suggested that cryoablation had advantages over radiofrequency ablation in terms of rehospitalizations and repeat procedures; however, the validity of these results must be questioned.

Refers to Kuck, K. H. et al. Cryoballoon or radiofrequency ablation for paroxysmal atrial fibrillation. N. Engl. J. Med.374, 2235–2245 (2016) | Kuck, K. H. et al. Cryoballoon or radiofrequency ablation for symptomatic paroxysmal atrial fibrillation: reintervention, rehospitalization, and quality-of-life outcomes in the FIRE AND ICE trial. Eur. Heart J.http://dx.doi.org/10.1093/eurheartj/ehw285 (2016)

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