TARGETED THERAPIES: Remembrance of things past — discontinuation of second-generation TKI therapy for CML

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Data from the recent Stop 2G-TKI study confirm that around 60% of patients with chronic myeloid leukaemia who discontinue second-generation BCR-ABL1 tyrosine-kinase inhibitor (TKI) therapy after a sustained deep molecular response remain in remission for longer than 1 year. Importantly, the interim findings suggest that prior response to first-line TKI treatment might predict relapse risk after treatment discontinuation.

Refers to Rea, D. et al. Discontinuation of dasatinib or nilotinib in chronic myeloid leukaemia: interim analysis of the Stop 2G-TKI study. Blood–09–742205 (2016)

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