Jena D. French and Bryan R. Haugen are at the Department of Medicine, Division of Endocrinology, University of Colorado Cancer Center, University of Colorado School of Medicine, 12801 E. 17th Avenue, Campus Box 8106, Aurora, Colorado 80045, USA.
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In the current era of immunotherapy successes, Min and colleagues report the promising preclinical development and efficacy of a CAR T cell therapy that recognizes ICAM-1, which is highly expressed in advanced thyroid cancers. Herein, we discuss the feasibility of this approach and its implications for future therapies to treat thyroid cancer.Refers to Min, I. M. et al. CAR T therapy targeting ICAM-1 eliminates advanced human thyroid tumours. Clin. Cancer Res.http://dx.doi.org/10.1158/1078-0432.CCR-17-2008 (2017)