Chronic inflammation is a well-known risk factor for developing colitis-associated colorectal cancer. A new study reports that aberrant activation of innate immune responses increases susceptibility to colitis and colorectal cancer. These findings identify an epithelial cell-intrinsic mechanism by which the innate immune system promotes tumorigenesis through the activation of PI3K-mTOR signalling.
Refers to Karki, R. et al. NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature 540, 583–587 (2016)