COLORECTAL CANCER: A new innate immune sensor — functions from inside the colonic epithelium

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Chronic inflammation is a well-known risk factor for developing colitis-associated colorectal cancer. A new study reports that aberrant activation of innate immune responses increases susceptibility to colitis and colorectal cancer. These findings identify an epithelial cell-intrinsic mechanism by which the innate immune system promotes tumorigenesis through the activation of PI3K-mTOR signalling.Refers to Karki, R. et al. NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature 540, 583–587 (2016)

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