LIVER: Taking out the JuNK to treat α1-antitrypsin deficiency

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New work has provided insight into the molecular pathways that underlie the liver disease that is associated with α1-antitrypsin deficiency, and has identified a novel approach to cell-based therapy.

Refers to Pastore, N. et al. Activation of JNK pathway aggravates proteotoxicity of hepatic mutant Z alpha1-antitrypsin. Hepatology (2017) | Baligar, P. et al. Bone marrow stem cell therapy partially ameliorates pathological consequences in livers of mice expressing mutant human α1-antitrypsin. Hepatology (2017)

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