Cell culture infection models help to develop antiviral agents, but animal models are required to understand complex virus-host interactions and the development of immune therapies. Although identification of the HBV uptake receptor enabled establishing cell lines that replicate HBV from its natural transcription template, animal models supporting the full HBV life cycle are still lacking.
Refers to Lempp, F. A. et al. Sodium taurocholate cotransporting polypeptide is the limiting host factor of hepatitis B virus infection in macaque and pig hepatocytes. Hepatologyhttp://dx.doi.org/10.1002/hep.29112 (2017) | Yan, Z. et al. HBVcircle: a novel tool to investigate hepatitis B virus covalently closed circular DNA. J. Hepatol.http://dx.doi.org/10.1016/j.jhep.2017.02.004 (2017)