At the squamocolumnar junction of mice and humans, a new study has identified a unique population of transitional basal cells that express molecular markers of both oesophageal stratified squamous epithelium and gastrointestinal columnar epithelium. These transitional basal cells are an attractive candidate for the cell of origin for Barrett oesophagus.
Refers to Jiang, M. et al. Transitional basal cells at the squamous-columnar junction generate Barrett's oesophagus. Nature550, 529-533 (2017)