ALZHEIMER DISEASE: The quest for Alzheimer disease genes—focus on CSF tau

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Alzheimer disease (AD)-associated loci identified by genome-wide association studies (GWAS) only partly explain the genetic risk for this common neurodegenerative dementia. A recent GWAS of an alternative phenotype—cerebrospinal fluid tau levels—has uncovered new genetic variants that might further account for risk of AD and provide novel pathophysiological insights.

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