Changes in DNA methylation patterns are emerging as an important feature in the development and progression of primary Sjögren syndrome. However, questions remain regarding the contribution of epigenetic (and genetic) factors to the recruitment and activation of autoreactive lymphocytes in the glandular tissues primarily affected by the disease.
Refers to Cole M. B. et al. Epigenetic signatures of salivary gland inflammation in Sjögren's syndrome. Arthritis Rheumatol.http://dx.doi.org/10.1002/art.39792 (2016)