OSTEOARTHRITIS: Inflammation and fibrosis in adipose tissue of osteoarthritic joints

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The infrapatellar fat pad and other adipose tissues in close proximity to the joint have been linked with osteoarthritis (OA), but the nature of this relationship is unclear. Two new studies elucidate the features of intra-articular adipose tissues in OA and raise important questions for future investigations.Refers to Eymard, F. et al. Knee and hip intra-articular adipose tissues (IAATs) compared with autologous subcutaneous adipose tissue: a specific phenotype for a central player in osteoarthritis. Ann. Rheum. Dis.http://dx.doi.org/10.1136/annrheumdis-2016–210478 (2017) | Barboza, E. et al. Pro-fibrotic infrapatellar fat pad remodeling without M1-macrophage polarization precedes knee osteoarthritis in diet-induced obese mice. Arthritis Rheumatol.http://dx.doi.org/10.1002/art.40056 (2017)

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