1EMBL–European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 2Department of Biology, University of Rome Tor Vergata, Rome, 00133, Italy, 3Institut de Biologie et Chimie des Protéines, UMR5086 CNRS/Lyon1 University, 69367, France, 4The J. Craig Venter Institute, Rockville, Maryland, MD 20850, USA, 5Department of Molecular Biology and Biochemistry—Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada, 6Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA, 7Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA and 8Department of Energy Institute for Genomics and Proteomics, University of California, Los Angeles, Los Angeles, CA 90095, USA
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The Proteomics Standard Initiative Common QUery InterfaCe (PSICQUIC) specification was created by the Human Proteome Organization Proteomics Standards Initiative (HUPO-PSI) to enable computational access to molecular-interaction data resources by means of a standard Web Service and query language. Currently providing >150 million binary interaction evidences from 28 servers globally, the PSICQUIC interface allows the concurrent search of multiple molecular-interaction information resources using a single query. Here, we present an extension of the PSICQUIC specification (version 1.3), which has been released to be compliant with the enhanced standards in molecular interactions. The new release also includes a new reference implementation of the PSICQUIC server available to the data providers. It offers augmented web service capabilities and improves the user experience. PSICQUIC has been running for almost 5 years, with a user base growing from only 4 data providers to 28 (April 2013) allowing access to 151 310 109 binary interactions. The power of this web service is shown in PSICQUIC View web application, an example of how to simultaneously query, browse and download results from the different PSICQUIC servers. This application is free and open to all users with no login requirement (http://www.ebi.ac.uk/Tools/webservices/psicquic/view/main.xhtml).