Gene loops and HDACs to promote transcription directionality

    loading  Checking for direct PDF access through Ovid


Gene loops have been described in different organisms from yeast to human and form through interaction between components of the transcription pre-initiation complex and Ssu72, a member of the 3′ end cleavage and polyadenylation complex. A recent study by Tan-Wong et al. reports a new role for gene loops in promoting ORF transcription directionality from otherwise bidirectional promoters.

Related Topics

    loading  Loading Related Articles