The objectives of this study were to examine the psychometric properties of the modified Care Dependency Scale in a pediatric setting and to explore the extent of dependency of school-aged children regarding their self-care. The data were collected from 130 hospitalized children, aged 6–12 years. The reliability was determined by Cronbach's alpha, which showed a high level of consistency. The subsequent inter-rater reliability revealed moderate-to-substantial agreement. The criterion-related validity was tested by comparing the sum scores of the Care Dependency Scale for Paediatrics and the Visual Analog Scale. Factor analysis was used to investigate the construct validity and resulted in a one-factor solution. In conclusion, this study provides evidence that the Care Dependency Scale for Paediatrics is a valid and reliable measure that offers a comprehensive assessment from a nursing perspective and enables nurses to help children acquire independence.