Evaluation of the effect of levocetirizine on nasal mucociliary clearance in allergic rhinitis patients by rhinoscintigraphy

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Abstract

Objective

The purpose of this study was to assess the effect of levocetirizine on nasal mucociliary clearance in allergic rhinitis patients using rhinoscintigraphy.

Methods

Twenty patients with allergic rhinitis (12 males and eight females, mean age 37.7±10.5 years) were evaluated. All the patients received levocetirizine (5 mg·day−1) for 4 weeks, and the speed of nasal mucociliary clearance was assessed before and after treatment. Twenty healthy controls (11 males and nine females, mean age 39.4±7.8 years) were also evaluated.

Results

The clearance values obtained for the treated group before and after treatment were significantly lower than those of the control group (P=0.0001), but there was no significant difference in clearance speeds before and after treatment in the patient group (P=0.444).

Conclusion

The study demonstrated that levocetirizine did not affect the speed of nasal mucociliary clearance in allergic rhinitis patients, and that nasal mucociliary clearance can easily be evaluated by rhinoscintigraphy.

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