Cardiac neuroendocrine tumour metastases: case reports and review of the literature

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Most neuroendocrine tumours (NETs) metastasize to the liver, lymph nodes and, although less frequently, to the bone. The heart is a rare localization for NET metastases.


With the introduction of the 68Ga-DOTATATE PET/computed tomography (CT) in our hospital as a new diagnostic method for imaging neuroendocrine tumours, more rare metastatic localizations are being found. We present six cases of patients with cardiac NET metastases detected by 68Ga-DOTATATE PET/CT. Also, a review of literature is presented on case reports of cardiac NET metastases in patients detected by somatostatin receptor imaging, including 111In-Pentetreotide single photon emission computed tomography/CT, 68Ga-DOTATATE PET/CT, 68Ga-DOTANOC PET/CT or 68Ga-DOTATOC PET/CT.

Results and Conclusion

Most patients with cardiac NET metastases have extensive metastatic disease. The cardiac metastases are often asymptomatic.

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