Impact of the activity calculation method used in transarterial radioembolization: a dosimetric comparison between 90Y-SIRSphere and 90Y-TheraSphere therapy

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Abstract

Purpose

Transarterial radioembolization is used to treat primary and secondary liver malignancies. Two commercially available drugs are utilized for the purpose. The aim of our study is to compare the radiation dose delivered to the tumor by these drugs.

Materials and methods

This study included 86 patients (M : F – 7.6 : 1, median age=50.5 years), 46 patients were treated by 90Y-TheraSphere and 42 patients were treated by 90Y-SIRSphere. Activity administered in 90Y-TheraSphere and 90Y-SIRSphere was calculated using a modified partition model and a modified body surface area model, respectively. The radiation dose delivered by two drugs was calculated and compared in our study.

Result

Activity administered in 90Y-TheraSphere was significantly higher than that of 90Y-SIRSphere. Hence, the radiation dose delivered to the tumor by 90Y-SIRSphere was significantly lower (58.4%) than that of 90Y-TheraSphere (P=0.000).

Conclusion

As the radiation dose delivered by 90Y-SIRSphere was lower than 90Y-TheraSphere, we believe that the formula for 90Y-SIRSphere activity calculation needs to be modified so that the optimal dose can be delivered to the tumor.

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