Concentration protocol of rhenium-188 perrhenate eluted from tungsten-188/rhenium-188 generator for the preparation of high-yield rhenium-188-labelled radiopharmaceuticals

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Abstract

Rhenium-188 (188Re) is a β, γ emitter and considered a theranostic radionuclide. It is used for bone pain palliation, treatment of unresectable hepatocellular carcinoma, skin keloids, etc. 188Re perrhenate is eluted from a 188W/188Re generator in large volumes (8–14 ml) of 0.9% normal saline. Concentrating 188Re to 1–2 ml volume is important for high radiolabelling yield of various 188Re radiopharmaceuticals, especially when the generator is old. For this, ion exchange column was prepared in-house, and 188Re was concentrated using silver ion exchange column and QMA cartridge. 188Re perrhenate eluted in saline was concentrated to 1 ml with more than 99% yield.

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