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Health care architecture and design are critical resources that are often underestimated and overlooked. As we seek to extract every available resource at our disposal to serve patients and sustain the bottom line, it is vital that we consider the influence the building imposes on the patient and caregiver experiences. Buildings impact both caregiver behaviors and the economic enterprise and are, therefore, the business of health care executives. This understanding is not only an executive obligation, it is an executive opportunity. Furthermore, the built environment can be a source for innovation in an industry whose future depends on nurse leaders to champion ingenuity with simplicity and relevance. Nurse leaders are ideally positioned to bridge health care building design and best practice.