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Approximately 1 to a million Americans suffer from Paget's disease of the bone. This chronic disease often results in pain, deformity, and mobility imairments, and can dramatically impair a patient's quality of life. The primary care provider plays a pivotal role in diagnosing and managing the patient with Paget's disease. This artile discusses Paget's disease diagnosis, management, pharmacologic therapy, referral, and follow-up.