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A large prospective cohort study of perineal talc use demonstrated no increased risk of ovarian cancer overall or within any histological subtype. In addition, no association with talc application method was observed.Houghton SC, et al. Perineal powder use and risk of ovarian cancer. J Natl Cancer Inst 2014;106:dju208 doi:10.1093/jnci/dju208.