Screening for Fetal Chromosome Abnormalities: What Combination Makes the Most Sense?

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Abstract

SYNOPSIS:

Recent studies using data from the California Prenatal Screening Program show that standard screening protocols, which combine first trimester ultrasound and biochemistry with second trimester biochemistry, has a very acceptable detection rate and outperforms NIPT in cost-effectiveness in low-risk patients.

SOURCES:

Baer RJ, et al. Detection rates for aneuploidy by first trimester and second trimester screening. Obstet Gynecol 2015;126:753-759.

SOURCES:

Kaimal AJ, et al. Prenatal testing in the genomic age: Clinical outcomes, quality of life, and costs. Obstet Gynecol 2015;126:737-746.

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