(Reg Anesth Pain Med. 2015;40(5):583–588)
Spinal anesthesia is associated with adverse effects such as arterial hypotension and bradycardia. The goal of this study was to evaluate the efficacy of 2 serotonin receptor antagonists in preventing these effects. Ramosetron is a receptor antagonist that is stronger and longer-lasting than others of its kind and has been observed to decrease hypotension resulting from spinal anesthesia. Ondansetron is another receptor antagonist that has been reported to diminish spinal-anesthesia–related hypotension in both obstetric and nonobstetric patients.