Division of Anesthesiology, Intensive Care and Emergency Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
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(Anesthesiology. 2016;125(2):263–265)The potential risk to the developing human brain of general anesthetic exposure has been a topic of interest to both anesthesiologists and the public. Several research endeavors in addition to those by the public/private International Anesthesia Research Society/US Food and Drug Administration initiative SMARTTots (http://www.smarttots.org) and the European Society of Anaesthesiology-sponsored (Brussels, Belgium) EuroStar” consortium (http//www.esahq.org/research/research-groups/eurostar) have been undertaken in an attempt to elucidate the effects of anesthesia and keep parents informed as they make decisions regarding surgery and anesthesia in their infants and young children.