Do Labetalol and Methyldopa Have Different Effects on Pregnancy Outcome? Analysis of Data From the Control of Hypertension In Pregnancy Study (CHIPS) Trial

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(BJOG. 2016;123:1143–1151)The Control of Hypertension In Pregnancy Study (CHIPS trial) investigated the impact of a target blood pressure (BP) on maternal and perinatal outcomes by randomizing women with gestational or preexisting hypertension to a diastolic BP target of 100 (“less tight” control group) versus 85 mm Hg (“tight” control group). The present study, a secondary analysis of the CHIPS trial data, aimed to compare pregnancy outcomes between women taking methyldopa or labetalol while considering the allocation of these patients to the “less tight” or “tight” control group.

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