IV Paracetamol as an Adjunct to Patient-controlled Epidural Analgesia With Levobupivacaine and Fentanyl in Labour: A Randomized Controlled Study

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Abstract

(Br J Anaesth. 2016;117:617–622)

Neuraxial techniques are the accepted gold standard for intrapartum labor analgesia but adjunctive agents may help to provide a dose-sparing effect. Paracetamol is an effective antipyretic and analgesic medication with established tolerability and a favorable safety profile. However, very few studies have assessed its intrapartum use, and no study has evaluated intravenous (IV) paracetamol as an adjunct analgesic agent for labor analgesia regimens. The authors of the present study thus evaluated the efficacy of a 1000 mg IV. infusion of paracetamol as an adjunct and its sparing effect on total levobupivacaine and fentanyl consumption.

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