Predictive Accuracy of Serial Transvaginal Cervical Lengths and Quantitative Vaginal Fetal Fibronectin Levels for Spontaneous Preterm Birth Among Nulliparous Women

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(JAMA. 2017;317(10):1047–1056)

Since preterm delivery is a major cause of infant mortality, high medical costs, and long-term health effects, finding a way to predict such deliveries would be useful. Previous studies have shown mixed results when evaluating the association between cervical length or the existence of fetal fibronectin in cervicovaginal fluid with the risk of spontaneous preterm delivery. The current prospective observational cohort study was undertaken to evaluate the accuracy of universal screening in nulliparous pregnant women that included serial measurements of cervical lengths and quantitative vaginal fetal fibronectin levels for predicting spontaneous premature births.

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