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(Anesth Analg. 2017;124(4):1211–1218)Remifentanil is a short-acting opioid. Its use for labor analgesia is controversial because of reports of associated apnea. The aim of this study was to perform a secondary analysis of respiratory data from a previous study of laboring women using patient-controlled intravenous (IV) remifentanil analgesia, in order to evaluate physiologic variables as early warning alerts of apnea.