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(Int J Obstet Anesth 2017;32:41–47)Hypotension is common in woman receiving spinal anesthesia for cesarean delivery and can adversely affect uteroplacental perfusion. While phenylephrine is now generally considered the vasopressor of choice for treatment of spinal-induced hypotension, ephedrine is also still frequently used in certain situations, such as in the setting of maternal bradycardia. Although these drugs are commonly administered during cesarean delivery, there are limited data about their effects on the neonate. This current multicenter, randomized controlled study compared the effects of ephedrine and phenylephrine on neonatal vital signs and blood glucose concentrations shortly after cesarean delivery.