Effects of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-ischemic Encephalopathy

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(JAMA 2017;318(16):1550–1560)Previous trials have shown therapeutic hypothermia reduces death or disability when infants with hypoxic-ischemic encephalopathy are treated within 6 hours after birth. Getting infants treated in this window can be difficult when transportation is necessary or when encephalopathy is not recognized within 6 hours. This study aimed to determine whether hypothermia treatment can reduce the risk of death or disability due to hypoxic-ischemic encephalopathy at 18 months when treatment is initiated between 6 and 24 hours after birth.

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