Placental Histopathology of Midtrimester Termination

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Placentas spontaneously passed after second-trimester terminations of pregnancy using either hypertonic sodium chloride or hyperosmolar urea plus prostaglandin F2α(PGF2α) were examined to determine histologic characteristics. The placentas of hypertonic sodium chloride terminations demonstrated a type of “coagulation necrosis” that has been described previously, while placentas of pregnancies terminated by hyperosmolar urea plus PGF2α showed a similar pattern in about one half the cases but a histologic pattern of less severe damage in the remaining cases. The 2 groups showed no significant differences when characteristics such as injection-abortion interval or estimated hypertonicity of the fluid were examined.

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