Glycosylated Hemoglobins in Normal Pregnancy and Gestational Diabetes Mellitus

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Glycosylated hemoglobins (HbA1) were measured in 23 nonpregnant women, 53 normal pregnant women, and 22 Class A diabetics; the results were 6.1 ± 0.7%, 5.8 ± 1.0%, and 7.0 ± 1.3% in the 3 groups, respectively. The decrease in normal pregnancy was insignificant, whereas the increase of HbA1 in Class A diabetics over the other 2 groups was statistically significant (P < 0.05). HbA1 did not correlate with maternal age, gravidity, or gestational age at the time of sampling. There was no difference in HbA, between whites and blacks [patients with sickle hemoglobin (HbS) were excluded] (P= 0.35), nor between primigrav-idas and multigravidas (P= 0.8). HbA, levels did not correlate with the birth weight ratios in either normal pregnancies (r= 0.06, P= 0.7) or in Class A diabetics (r= −0.4, P= 0.09). This is probably due to the long interval between HbA, determination and delivery (9.9 weeks).

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