Transforming Growth Factor-β Activity is Increased in Peritoneal Fluid From Women With Endometriosis

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Abstract

Objective:

To investigate the presence of transforming growth factor-/} in peritoneal fluid of women with and without endometriosis.

Methods:

Fifty-two peritoneal fluid samples, obtained during laparoscopies performed for tubal ligation (π =10), infertility (it=38), or pain (n=4), were examined for the presence of transforming growth factor-β } using the MvlLu cell growth inhibition assay. At laparoscopy, 26 women had endometriosis. The other 26 women had no endometriosis; 16 of them had infertility, and ten who had no pelvic pathology at tubal sterilization served as fertile controls.

Results:

The concentration of transforming growth factor-β was increased in the peritoneal fluid from women with endometriosis (11.4 ± 3.3 ng/ mL) compared to both the fertile control group without endometriosis (1.1 ± 0.29 ng/ mL) and the infertile control group without endometriosis (3.6 ± 1.4 ng/ mL). Twenty-five of the 52 women (48% demonstrated levels of transforming growth factor-β ? higher than 2 ng/ mL. Patients with endometriosis were significantly more likely to have elevated concentrations of transforming growth factor-0 than were women without endometriosis (16 of 26, 61.5% versus nine of 26, 34.6%.

Conclusions:

These findings demonstrate the presence of transforming growth factor-β) in peritoneal fluid. Elevated levels in women with endometriosis could be important in the pathophyslology of this disease. (Obstet Gynecol 1994; 83:287-92)

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