Preterm Birth Rate Following Surgical Correction of Uterine Septum/Arcuate Uterus in Singleton Gestations [30E]

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Abstract

INTRODUCTION:

This study compared preterm birth rate, gestational age at delivery and neonatal birth weights in singleton gestations, in a cohort of women with primary infertility and a surgically corrected uterine anomaly to those with normal uterine cavity.

METHODS:

This retrospective cohort study included 265 patients between 1992–2011. The study group (106 patients) had primary infertility patients with hysteroscopically corrected incomplete uterine septum or arcuate uterus. The control group (159 patients) had primary infertility with normal uterine cavity by hysteroscopic evaluation. All patients conceived a singleton gestation via spontaneous conception (SC), or intrauterine insemination after controlled ovarian stimulation (IUI+COS), or in vitro fertilization and embryo transfer (IVF-ET).

RESULTS:

There was no significant difference in patient age, BMI, day 3 FSH levels, the incidence of male factor infertility or ovulatory disorders between the two groups. There was significantly lower duration of infertility (P<.01), incidence of tubal factors (P<.001) and endometriosis (P<.001) in the study group compared to the control group. There was no statistically significant differences in the incidence of preterm birth (17.9% vs 22.6%), mean gestational age at delivery in weeks (37.6±5.3 vs 37.9±3.8) and birth weight in kg (3.2+0.6 vs 3.3±0.6) between the study group and the control group respectively.

CONCLUSION:

Our data suggest that in patients with primary infertility and hysteroscopically corrected incomplete uterine septum or arcuate uterus, the incidence of preterm birth, gestational age, and birth weight appear to be similar to those patients with normal uterine cavities.

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