Preterm Birth and IVF-ET in Singleton Pregnancy After Hysteroscopic Correction of Uterine Septum [27H]

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Abstract

INTRODUCTION:

The purpose of this study is to compare preterm birth rate in a cohort of women with primary infertility, and hysteroscopically corrected incomplete uterine septum or arcuate uterine anomaly, who subsequently conceived singleton gestation via spontaneous conception (SC), or intrauterine insemination after controlled ovarian stimulation (IUI+COS) or IVF-ET.

METHODS:

This retrospective study included women with primary infertility and incomplete uterine septum or arcuate uterine anomaly. All patients underwent successful hysteroscopic septoplasty that resulted in a normal uterine cavity postoperatively between 1992–2011. Subsequently all patients conceived singleton gestation by SC, IUI+COS, or IVF-ET. The study included 106 patients, 45 conceived spontaneously, 11 with IUI+COS, and 50 with IVF-ET. The primary outcome was the preterm birth rate. Secondary outcomes were gestational age at delivery and neonatal birth weight.

RESULTS:

There was a significant difference in age, but no significant differences in duration of infertility, BMI, day 3 FSH levels or underlying etiology among the three groups. There was no statistical difference in preterm birth rates (17.8% vs 27.3% vs 16%), mean gestational age at delivery in weeks (38.6±2.5 vs 37.6±3.6 vs 36.6±7.0), and birth weight in Kg (3.3±0.6 vs 3.1±0.8 vs 3.2±0.7) between SC, IUI+COS, and IVF-ET groups respectively.

CONCLUSION:

Our data suggest that in patients with incomplete uterine septum or arcuate uterine anomaly, who underwent successful hysteroscopic correction, IVF-ET treatment per se is not associated with increased risk of preterm birth and/or low birth weight.

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