Cardiovascular Disease Risk Factors Among Women With Preterm Preeclampsia [13K]

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Preterm preeclampsia is associated with a 2–4 fold increased risk of subsequent early onset of cardiovascular disease (CVD). We evaluated whether women with preterm preeclampsia were more likely to have CVD risk factors in the postpartum period than women with preterm birth without preeclampsia.


This retrospective chart review was conducted at an academic center. Inclusion criteria were a singleton preterm infant less than 35 weeks and available medical records. Records were reviewed for sociodemographic characteristics, pregnancy course, post-delivery clinical care. The risk factors for CVD were: diabetes and prediabetes, hypertension, hyperlipidemia, smoking, overweight or obese, family history of CVD, history of preeclampsia. Women with and without preeclampsia were the comparative groups.


Among the 113 women, 32% had preeclampsia. The comparative groups delivered at a similar gestational age (28.2±2.7 vs 28.6±4.7 weeks, P=.63) but the infants of women with preeclampsia were smaller (1141±552 vs 1305±506 gm, P=.03). Women with preeclampsia had a higher prepregnancy BMI (28.8±8 vs 25±6 kg/m2, P=.04) but had similar gestational weight gain (7.6±1.3 vs 5.2±0.7 kg, P=.06) and weight retention (1.5 vs 3.8 kg, P=.06). There was no difference in primary care follow up within 1 year after delivery (29 vs 30%, P=.9) but women with preeclampsia had more CVD risk factors (1 [0–3] vs 1 [0–1]), P<.001).


Women with preterm preeclampsia have more risk factors for CVD before pregnancy and after delivery. This may partially explain the observation of the high rates of subsequent CV disease among this group.

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