The Accuracy of Frozen Section Pathology in the Staging of Endometrial Cancer: A Retrospective Study [12P]

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Abstract

INTRODUCTION:

Endometrial cancer is the most common gynecologic malignancy in the United States. Endometrial cancer treatment and prognosis is dependent on the severity and spread of disease. In order to determine severity and spread we depend upon surgical staging and pathologic evaluation including intra-operative frozen section (IFS) and permanent section (PS).

METHODS:

A retrospective chart analysis between Jan 2013–Dec 2014 of patients diagnosed with endometrial cancer after permanent pathologic evaluation. Exclusion criteria: no frozen section, previous pelvic radiation, clinically advanced disease, coexisting second malignancy, and uterine sarcoma. Chi square analysis of IFS vs PS grade, histologic type, and depth of invasion of tumor. The primary outcome was to determine the accuracy of intraoperative frozen section to permanent section pathology in patients with endometrial cancer.

RESULTS:

There were 111 cases of endometrial cancer identified between Jan2013–Dec 2014. Of these a total 68 pts analyzed after exclusion criteria. Using IFS to identify lower risk disease prior to performing comprehensive staging can be beneficial to reduce these risk. IFS histologic type was strongly correlated to PS with a P value of <.0001. IFS depth of invasion was strongly correlated to PS a P value of <.0001.

CONCLUSION:

Using IFS to identify lower risk disease prior to performing comprehensive staging can be beneficial. IFS accurately identifies grade, histologic type, and depth of invasion of endometrial cancer when compared to PS at this institution. IFS can be used as a resource for gyn oncologists to determine whether to proceed with comprehensive staging.

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