Duration of Latency Period and Histologic Chorioamnionitis in Patients With PPROM From 24 to 32 Weeks [24Q]

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The study objective was to determine if rates of histologic chorioamnionitis (HC) increased with longer latency periods.


This was a retrospective cohort study at a single institution from 1/1/2001 to 12/31/14 of patients admitted for conservative management with PPROM between 24 0/7 to 32 6/7 weeks. Patient were excluded if they were not a candidate for expectant management, multifetal gestation, HIV positive, delivered prior to hospital day 2 or did not have placental pathology results available. Patients were grouped by days from admission to delivery and rates of HC were compared. Mann-Whitney, Chi-square and Fisher's exact tests were used.


143 patients were included, 97 (68%) had HC. Median gestational age at time of PPROM was lower in the HC group (28 compared to 30 weeks, P=.004). The median latency period with and without HC were 6 (range 2–36) and 9 days (range 2–53), respectively (P=.047). For the group with a latency of 2–7 days, the rate of HC was 75%, similar to those who delivered from 8–14 days (70%, P=.75). HC in patients who delivered after 14 days was 42%, lower than the day 2–7 group (P=.0045). Clinical chorioamnionitis was similar between the two groups (HC 17.4%; no HC 21.6%, P=.66). The latency period did not differ in patient with and without clinical chorioamnionitis.


There was no increase in histologic chorioamnionitis as the latency period increased in this cohort. Although the overall rate is high, this data does not suggest a specific time point when delivery can be recommended.

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